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1. Gerbarg P. Muskin P. Brown R. Complementary and integrative treatments in psychiatric practice. American Psychiatric Association, Arlington, VA. 2017. Chapter 6.
2. Pauling, Linus. Orthomolecular Psychiatry Science, pages 160, 265-271, 1968. Quoted in: Hoffer A. Orthomolecular Treatment of Schizophrenia. Journal of Orthomolecular Medicine Vol. 24, No. 3 & 4, 2009. This paper was presented at the joint meeting of The American Schizophrenia Association, The Canadian Schizophrenia Association, and The Schizophrenia Association of Great Britain; London, England, September 28-30, 1971.
3. Popper CW. Single-micronutrient and broad-spectrum micronutrient approaches for treating mood disorders in youth and adults. Child Adolesc Psychiatr Clin N Am. 2014 Jul;23(3):591-672.
4. Bass C, Bond A, Gill D, Sharpe M. Frequent attenders without organic disease in a gastroenterology clinic. Patient characteristics and health care use. Gen Hosp Psychiatry. 1999 Jan-Feb;21(1):30-8.
5. Fadgyas-Stanculete M, Buga AM, Popa-Wagner A, Dumitrascu DL. The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations. J Mol Psychiatry. 2014 Jun 27;2(1):4.
6. http://www.merckmanuals.com/professional/clinical-pharmacology/factors-affecting-response-todrugs/drug-interactions 2018 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Accessed 16 February 2018.
7. Popper, C. (2010). Nutritional Management of Bipolar Disorder in Adults and Youth [Powerpoint slides]. Retrieved from https://integrativemedicine.arizona.edu/file/.../IMHC10_Popper_nutritionalmgmt.pdf
8. Lord RS, Bralley JA. Ed. Laboratory Evaluations for Integrative and Functional Medicine. 2nd Edition. Metametrix Institute. 2008.
9. Cox WM, Mueller AJ. Serum albumin regeneration as effected by intravenously and orally administered protein hydrolysates. J Clin Invest. 1944 Nov;23(6):875-9.
10. Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F, Wu Z. Glutamine and intestinal barrier function. Amino Acids. 2015 Oct;47(10):2143-54.
11. Wang B, Wu Z, Ji Y, Sun K, Dai Z, Wu G. L-Glutamine Enhances Tight Junction Integrity by Activating CaMK Kinase 2-AMP-Activated Protein Kinase Signaling in Intestinal Porcine Epithelial Cells. J Nutr. 2016 Mar;146(3):501-8.
12. Wang L, Maher TJ, Wurtman RJ. Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid. FASEB J. 2007 Apr;21(4):1227-32.
13. Rucklidge JJ. Could yeast infections impair recovery from mental illness? A case study using micronutrients and olive leaf extract for the treatment of ADHD and depression. Adv Mind Body Med. 2013 Summer;27(3):14-8.
14. Belum GR, Belum VR, Chaitanya Arudra SK, Reddy BS. The Jarisch-Herxheimer reaction: revisited. Travel Med Infect Dis. 2013 Jul-Aug;11(4):231-7.
15. Kong S, Zhang YH, Zhang W. Regulation of Intestinal Epithelial Cells Properties and Functions by Amino Acids. Biomed Res Int. 2018 May 9;2819154.
16. Simpson JSA, Crawford SG, Goldstein ET, Field C, Burgess E, Kaplan BJ. Safety and tolerability of a complex micronutrient formula used in mental health: A compilation of eight datasets. BMC Psychiatry. 2011;11:62.
17. Rucklidge JJ, Eggleston MJF, Johnstone JM, Darling K, Frampton CM. Vitamin-mineral treatment improves aggression and emotional regulation in children with ADHD: a fully blinded, randomized, placebo-controlled trial. J Child Psychol Psychiatry. 2018 Mar;59(3):232-246.
18. Martinez A, Knappskog PM, Haavik J. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Curr Med Chem. 2001 Jul;8(9):1077-91.
19. Park KH, Lee JR, Hahn HS, Kim YH, Bae CD, Yang JM, Oh S, Bae YJ, Kim DE, Hahn MJ. Inhibitory effect of ammonium tetrathiotungstate on tyrosinase and its kinetic mechanism. Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1266-70.
20. Hutto BR. Folate and cobalamin in psychiatric illness. Compr Psychiatry. 1997 Nov-Dec;38(6):305-14.
21. Bell IR, Edman JS, Morrow FD, Marby DW, Perrone G, Kayne HL, Greenwald M, Cole JO. Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. J Am Coll Nutr. 1992 Apr;11(2):159-63.
22. Baldewicz TT, Goodkin K, Blaney NT, Shor-Posner G, Kumar M, Wilkie FL, Baum MK, Eisdorfer C. Cobalamin level is related to self-reported and clinically rated mood and to syndromal depression in bereaved HIV-1(+) and HIV-1(-) homosexual men. J Psychosom Res. 2000 Feb;48(2):177-85.
23. McCarty MF. High-dose pyridoxine as an ‘anti-stress’ strategy. Med Hypotheses. 2000 May;54(5):803-7.
24. Shaw I., Rucklidge J. J., Hughes R. N. A possible biological mechanism for the B Vitamins altering behaviour in ADHD. Pharmaceutical Medicine. 2010;24(5):1-6.
25. Huang EP. Metal ions and synaptic transmission: think zinc. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13386-7.
26. Frederickson CJ, Suh SW, Silva D, Frederickson CJ, Thompson RB. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr. 2000 May;130(5S Suppl):1471S-83S.
27. Cohen-Kfir E, Lee W, Eskandari S, Nelson N. Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission. Proc Natl Acad Sci USA. 2005 Apr 26;102(17):6154-9.
28. Wall MJ. A role for zinc in cerebellar synaptic transmission? Cerebellum. 2005;4(4):224-9.
29. Takeda A. Movement of zinc and its functional significance in the brain. Brain Res Brain Res Rev. 2000 Dec;34(3):137-48.
30. Reynolds IJ, Miller RJ. Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc. Br J Pharmacol. 1988 Sep;95(1):95-102.
31. Siwek M, Wrobel A, Dudek D, Nowak G, Zieba A. The role of copper and magnesium in the pathogenesis and treatment of affective disorders. Psychiatr Pol. 2005 Sep-Oct;39(5):911-20.
32. Schlief ML, Gitlin JD. Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus. Mol Neurobiol. 2006 Apr;33(2):81-90.
33. Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. American Journal of Clinical Nutrition. 2002 Apr;75(4):616-58.
34. Pejchal R, Campbell E, Guenther BD, Lennon BW, Matthews RG, Ludwig ML. Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation. Biochemistry. 2006 Apr 18;45(15):4808-18.
35. Kaplan BJ, Crawford S, Field C, Simpson JS. (2007). Vitamins, minerals, and mood. Psychological Bulletin. 133(5):747-760.
36. Halliwell C, Kolb B. (2003). Diet can stimulate functional recovery and cerebral plasticity after perinatal cortical injury in rats. Soc Neuro Abs. 29:459-411.
37. Brambilla P, Glahn DC, Balestrieri M, Soares JC. Magnetic resonance findings in bipolar disorder. Psychiatr Clin North Am. 2005 Jun;28(2):443-67.
38. Monkul ES, Malhi GS, Soares JC. Anatomical MRI abnormalities in bipolar disorder: do they exist and do they progress? Aust N Z J Psychiatry. 2005 Apr;39(4):222-6.
39. Emsell L, McDonald C. The structural neuroimaging of bipolar disorder. Int Rev Psychiatry. 2009;21(4):297-313.
40. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press, Washington, D.C., 1997.
41. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B-6, Folate, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., 1998.
42. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, D.C., 2000.
43. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes: Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, D.C., 2001.
44. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. National Academy Press, Washington, D.C., 2005.
45. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. National Academy Press, Washington, D.C., 2005.
46. Sathyanarayana Rao TS, Christopher R, Andrade C. Biotin supplements and laboratory test results in neuropsychiatric practice and research. Indian J Psychiatry. 2017 Oct-Dec; 59(4): 405–406.
47. Samarasinghe S, Meah F, Singh V, Basit A, Emanuele N, Emanuele MA, Mazhari A, Holmes EW. Biotin Interference with routine clinical immunoassays: understand the causes and mitigate the risks. Endocr Pract. 2017 Aug;23(8):989-998.
48. Drugbank.ca (At URL: https://www.drugbank.ca/drugs/DB00422#interactions, and search methylphenidate Drug Interactions for “calcium” or “magnesium”). Accessed Feb. 11, 2019.
49. Attri JP, Bala N, Chatrath V. Psychiatric patient and anaesthesia. Indian J Anaesth. 2012 Jan;56(1):8-13.
50. Becker DE. Psychotropic drugs: implications for dental practice. Anesth Prog. 2008 Fall;55(3):89-99.
51. Peck T, Wong A, Norman E. Anaesthetic implications of psychoactive drugs. Contin Educ Anaesth Crit Care Pain 2010;10(6):177-181.
52. Lurie I, Yang YX, Haynes K, Mamtani R, Boursi B. Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study. J Clin Psychiatry. 2015 Nov;76(11):1522-8.
53. Specter M. Germs are us. Annals of Science. The New Yorker. 2012 Oct 22.
54. Libby AF, Stone I. The hypoascorbemia - kwashiorkor approach to drug addiction therapy: a pilot study. Australas Nurses J. 1978 Jan-Feb;7(6):4-8, 13.
55. Guo LQ, Yamazoe Y. Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines. Acta Pharmacol Sin. 2004 Feb;25(2):129-36.
56. Ashton H. Protracted withdrawal syndromes from benzodiazepines. J Subst Abuse Treat. 1991;8:19-28.
57. Ashton H. Protracted withdrawal from benzodiazepines: The post-withdrawal syndrome. Psych Ann. 1995a; 25: 174-9.
58. Vanakoski J1, Seppälä T. Heat exposure and drugs. A review of the effects of hyperthermia on pharmacokinetics. Clin Pharmacokinet. 1998 Apr;34(4):311-22.
59. Furman KI. Effects of heat on drug action in man. Int J Biometer. November 1966, Volume 10, Issue 2, pp 169–174.
60. Kanter GS. Glomerular filtration and renal plasma flow during hyperthermia. Am J Physiol. 1960 May;198:1044-8.
61. Institute of Medicine. 2005. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC: The National Academies Press. https://doi.org/10.17226/10925.
62. Ylitalo P. Effect of exercise on pharmacokinetics. Ann Med. 1991 Aug;23(3):289-94.
63. Khazaeinia T, Ramsey AA, Tam YK. The effects of exercise on the pharmacokinetics of drugs. J Pharm Pharm Sci. 2000 Sep-Dec;3(3):292-302.
64. Dr. Bob Coleman Ph.D. PAS, University of Kentucky. Proceedings of the 2003 Alberta Horse Breeders and Owners Conference. https://www.albertahorseindustry.ca/hboc/2003/proceedings/which_minerals.pdf Accessed February 15, 2019.
65. Rodriguez NR, DiMarco NM, Langley S; American Dietetic Association; Dietitians of Canada; American College of Sports Medicine: Nutrition and Athletic Performance. Position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and athletic performance. J Am Diet Assoc. 2009 Mar;109(3):509-27.