As the world's leading formulator of micronutrients for brain health, Hardy Nutritionals® is committed to remaining at the forefront of nutrition research and development. As a result, we are pleased to introduce our newest supplement, Daily Essential Nutrients With Added Vitamers (DEN-V). This product is a powerful addition to our line-up of clinical micronutrients and is now available.

What are vitamers?
Vitamers are simply different forms of vitamins than the typical forms found in multivitamin supplements. For example, Vitamin B12 naturally consists of three vitamers, or different forms, all three of which are available in the new DEN With Added Vitamers formula. These include methylcobalamin, adenosylcobalamin, and hydroxocobalamin. 

Why add vitamers?
Vitamers allow the body to uptake different forms of vitamins which can sometimes have unique importance in the body. For example, providing all three forms of vitamin B12 rather than just one has been shown to support a healthy metabolism. When providing multiple vitamers for each vitamin, our formulation matches the food form of each vitamin better, which may ultimately provide better absorption and better efficacy.

Will the original Daily Essential Nutrients continue to be available?
Yes! You can still access the original Daily Essential Nutrients on our website or through your health care provider as usual. 

Who should use Daily Essential Nutrients With Added Vitamers?
DEN-V was primarily formulated for individuals with genetic mutations or other metabolic sensitivities such as people with methylation or lithium sensitivity. In addition, individuals who want a high-quality supplement that contains more of the natural food vitamers than are present in the original DEN would be good candidates for the new DEN-V.

For those people doing well on Daily Essential Nutrients, there is no real reason to switch to the DEN-V.  If however, you feel you may benefit from the added vitamers form, and would like to see if it makes a difference for you, then it is a great new option. 

What symptoms from taking the original DEN might indicate that DEN With Added Vitamers could be a better fit?
Increased anxiety, obsessive or intrusive thoughts, agitation, or insomnia for which medication interactions, gut health issues, yeast infections, etc. have been ruled out may be an indication of methylation issues (i.e. sensitivity to methylfolate and methylcobalamin). In addition, if you have blood or genetic tests showing altered vitamin B6 metabolism or folate metabolism, the DEN-V will likely be the best fit for you.

Will the new DEN-V work as well as the original DEN?
Not only will the original DEN research apply to the new DEN-V formula, we believe the new DEN-V formula will almost certainly be better for some people who may not be doing as well as they would like to be on the original DEN.    Every person has different genetics, diet, and microbiome and each individual has different specific needs. Because of this, some will find it more effective, and some may find it less effective. 

 On average, efficacy should be similar based on the following research:

A number of independent research studies documenting positive outcomes for various aspects of mental health have been performed on at least five different iterations of the Daily Essential Nutrients formulation – all slightly different, but substantially similar in the following ways:

• Complete
• Bioavailable
• Balanced

Beyond Hardy formulas, multiple high-quality studies on several different vitamin-mineral preparations of similar composition and dose have shown significant mental health benefits.

What are the differences between DEN and DEN-V?

• The new DEN-V contains all eight forms of Vitamin E, instead of only one.
  • We added four mixed tocopherols (high gamma) and four mixed tocotrienols (high delta)
  • Proven antioxidant benefits 
  • Demonstrated cardiovascular health benefits as well as anti-cancer effects
    • Note: The label on DEN-V may look like there is less Vitamin E in the formula, but there is not. The sum of all the beta, delta, & gamma tocopherols & tocotrienols listed in the proprietary blend plus the alpha-tocopherol listed in the supplement facts is the same total quantity as alpha-tocopherol found in the original DEN.
• The new DEN-V contains more Niacin in two forms
  • We added more nicotinamide riboside and introduced another form called nicotinic acid
  • Matches food ratios better, known improvements in absorption, transport, and gut microbiome effects
  • Not enough nicotinic acid to cause flushing
• The new DEN-V has an additional form of Vitamin B6
  • We added an additional form of B6 called pyridoxal-5-phosphate (P5P)
  • P5P is proven to be more safe and effective than pyridoxine for people with certain genetic mutations
• The new DEN-V has an additional form of Vitamin B12
  • We added hydroxocobalamin
  • DEN-V has all three of the main food vitamers of B12, the original DEN has two
  • Matches food forms better, supplies known improvements in metabolism
• The new DEN-V has additional forms of folate
  • We added folinic acid 
  • We now include both folinic acid and methylfolate
  • Provides known differences in metabolism
• The new DEN-V has no lithium orotate on the label
  • The mineral lithium is no longer listed as an added ingredient but is naturally present in the Great Salt Lake minerals provided in our proprietary blend at about 1/4 to 1/3 of the original DEN formulation value.
  • Lithium orotate is still present in trace amounts and has been shown to benefit mood.
• The new DEN-V has added iodine from Atlantic kelp
  • A great source of many trace minerals, high in antioxidants, including carotenoids and flavonoids, which help fight against disease-causing free radicals. 

Will dosing be the same?
The dosage instructions for Daily Essential Nutrients With Added Vitamers are the same as the original DEN. Clinical dosing remains four capsules, three times per day. We continue to recommend working up to the full dose over time, beginning with one capsule per dose the first day, two capsules per dose the second day, and so on up to four capsules three times per day. Taking six capsules twice daily should be as effective with DEN-V as with the original DEN.

Will the new DEN-V be more expensive than the original DEN?
There will be a price difference between Daily Essential Nutrients and Daily Essential Nutrients With Added Vitamers. The new DEN-V is available for $134.95 for a 360 capsule bottle, and $48.95 for a 120 capsule bottle. This is a slight price increase above the original DEN. The reason for the increase in cost is due to the fact that more ingredients are included and many of the ingredients are more expensive than the common vitamin ingredients. As always, we source only the highest quality and most pure ingredients from around the world.

Interested in trying out the new Daily Essential Nutrients With Added Vitamers? It is available now.

About Hardy Nutritionals®

Hardy Nutritionals® multivitamin-mineral products are powered by our proprietary NutraTek™ mineral delivery technology, which combines each mineral with specialized organic molecules—just like nature—to optimize absorption and distribution to body cells. Our flagship supplement, Daily Essential Nutrients, is widely considered to be the most research-backed micronutrient treatment.