Methylfolate and MTHFR
Dr. Benjamin Lynch found that a portion of his MTHFR patients developed anxiety, irritability, and other symptoms after taking methylfolate. He found that 50 to 100 mg of niacin ameliorated the effects.1
We also found that niacin (niacinamide) did, in fact, lessen anxiety and irritability when it developed in a small number of individuals who experienced these same symptoms after taking Hardy Nutritionals® Daily Essential Nutrients (DEN). DEN contains methyfolate, methylcobalamin, and choline, which are all methyl donors. Several of these individuals had previously tested positive for MTHFR polymorphisms.
1. http://mthfr.net/methylfolate-side-effects/2012/03/01/ Accessed 13 April 2018.