4.1 Side Effects
Side-effect-free intake ranges for vitamins and minerals have been established by the United States Institute of Medicine and comparable authorities around the world based on a comprehensive review of relevant data in adults and children.(20–25)
According to these intake ranges established by the Institute of Medicine, the most important clinically relevant side-effect of the therapeutic dosage of Daily Essential Nutrients is mild diarrhea and other mild gastrointestinal complaints in a small percentage of patients who are sensitive to therapeutic magnesium doses.
Regarding this effect, the Institute of Medicine states, “Although a few studies have noted mild diarrhea and other mild gastrointestinal complaints in a small percentage of patients at levels of 360 to 380 mg (15.0 to 15.8 mmol) per day, it is noteworthy that many other individuals have not encountered such effects even when receiving substantially more than this [level] of supplementary magnesium."(20)
The following treatment-emergent adverse events have been observed in patients with bipolar disorder, depression, ADHD, generalized anxiety disorder, mood lability and explosive rage, oppositional defiant disorder, Asperger syndrome, and Prader Willi syndrome:(1)
4.2 Drug Interactions